The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

Donald A. Berry

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The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

机译：临床癌症研究的英勇新世界：将临床实践与临床研究相结合的自适应生物标记物驱动的试验

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Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platfo

机译：临床试验是知识链中的最终链接，用于确定治疗进展的作用。不幸的是，从重要意义上讲，它们是最薄弱的环节。本文介绍了当今正在探索的两种设计：platfo

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《Molecular oncology. 》 |2015年第5期| 共9页
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Donald A. Berry;
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中图分类肿瘤学 ;
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1. Translating clinical trials to clinical practice: Outcomes of men with metastatic castration resistant prostate cancer treated with docetaxel and prednisone in and out of clinical trials [J] . TempletonA.J., Vera-BadilloF.E., WangL., Annals of oncology: official journal of the European Society for Medical Oncology . 2013 ,第12期

机译：将临床试验转化为临床实践：多西他赛和泼尼松治疗的转移性去势抵抗性前列腺癌男性的临床试验结果
2. Translating clinical trials to clinical practice: Outcomes of men with metastatic castration resistant prostate cancer treated with docetaxel and prednisone in and out of clinical trials [J] . TempletonA.J., Vera-BadilloF.E., WangL., Annals of oncology: official journal of the European Society for Medical Oncology . 2013 ,第12期

机译：将临床试验转化为临床实践：用多西紫杉醇和泼尼松治疗转移阉割抗阉割前列腺癌的男性的结果，进出临床试验
3. Integrating patient-reported outcomes into cancer symptom management clinical trials supported by the National Cancer Institute-sponsored clinical trials networks. [J] . Sloan JA, Berk L, Roscoe J, Journal of Clinical Oncology . 2007 ,第32期

机译：由国家癌症研究所赞助的临床试验网络支持，将患者报告的结果纳入癌症症状管理临床试验。
4. Translating Multiscale Cancer Models into Clinical Trials: Simulating Breast Cancer Tumor Dynamics within the Framework of the "Trial of Principle" Clinical Trial and the ACGT Project [C] . Eleni A. Kolokotroni, Georgios S. Stamatakos, Dimitra D. Dionysiou, IEEE International Conference on BioInformatics and BioEngineering . 2008

机译：将MultiSscale癌症模型转化为临床试验：在“原理试验”临床试验和ACGT项目的框架内模拟乳腺癌肿瘤动态
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. The Brave New World of clinical cancer research: Adaptive biomarker‐driven trials integrating clinical practice with clinical research [O] . Donald A. Berry 2015

机译：临床癌症研究的勇敢新世界：结合临床实践和临床研究的适应性生物标志物驱动的试验
7. Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design [O] . Jason K. Sicklick, Paul T. Fanta, Kelly Shimabukuro, 2016

机译：胆囊癌的基因组学：生物标志物驱动临床试验设计的情况
8. Restructuring the National Cancer Clinical Trials Enterprise. Report of the Clinical Trials Working Group of the National Cancer Advisory Board. [R] . 2005

机译：重组国家癌症临床试验企业。国家癌症咨询委员会临床试验工作组的报告。

The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

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