Aerial parts of Echinops echinatus (Family: Asteraceae) were subjected to in vivo hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan Desert, Pakistan. Hepatoprotective effects of pre-treatment with aerial parts (ethanolic extract) of E. echinatus (EE), (500 and 750 mg/kg/day, p.o., for 7 days) against CCl4 (0.75 ml/kg., s/c.) intoxicated rabbits were evaluated by serum biochemical parameters and liver histopathological observations. Silymarin (100 mg/kg/day, p.o., for 7 days) was used as a standard hepatoprotective drug. CCl4 intoxicated group had raised levels of SGOT, SGPT and ALP significantly but TB level was not raised as compared to normal control group. EE Extract (500 mg/kg) produced more significant results as compared to extract (750 mg/kg). However, (both doses of 500 and 750 mg/kg) showed hepatoprotection as obvious by significant reinstatement of levels of SGOT, SGPT, ALP and even TB as compared to CCl4 and Silymarin control groups. Histopathological examination of the liver tissue further corroborated these results. Therefore, the outcome of the present study supports the traditional beliefs on hepatoprotective effects of E. echinatus (aerial parts).
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机译：为了验证其传统的在肝胆疾病中的用途，巴基斯坦的Cholistan Desert的土著居民对Echinops echinatus（家庭：菊科）的高空部分进行了体内肝保护研究。用紫锥菊（EE）的地上部分（乙醇提取物）预处理（500和750 mg / kg /天，口服，持续7天）对CCl4（0.75 ml / kg。，s / c）的肝保护作用。通过血清生化参数和肝脏组织病理学观察评估了陶醉的兔子。水飞蓟素（100mg / kg /天，口服，持续7天）用作标准的肝保护药物。 CCl4中毒组与正常对照组相比，SGOT，SGPT和ALP水平显着升高，但TB水平未升高。与提取物（750 mg / kg）相比，EE提取物（500 mg / kg）产生了更为显着的结果。但是，与CCl4和水飞蓟素对照组相比，通过显着恢复SGOT，SGPT，ALP甚至TB的水平（两种剂量分别为500和750 mg / kg）显示出对肝脏的保护作用。肝组织的组织病理学检查进一步证实了这些结果。因此，本研究的结果支持了关于紫锥菊（空中部分）的保肝作用的传统观念。
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