Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1

摘要

The Prep1 homeodomain transcription factor is essential for embryonic development. 25% of hypomorphic Prep1i/i embryos, expressing the gene at 2% of the normal levels, survive pregnancy and live a normal-length life. Later in life, however, these mice dev