PFOS and ZnO Nanoparticles Induced Oxidative Stress in Liver, Gill and Head of Zebrafish

摘要

Oxidative stress to liver, gill and head of zebrafish (Danio rerio) induced by perfluorooctanesul phonic acid potassium salt (PFOS) and ZnO nanoparticles (Nano-ZnO) is investigated in this study. Activities of superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) contents were measured in liver, gill and head of zebrafish. The results demonstrated that both PFOS and Nano-ZnO single and co-exposure induced oxidative stress. In addition, PFOS plus Nano-ZnO exposure caused more serious oxidative stress than single-exposure at above exposure concentrations. Besides, compare with single-exposure, the activity of CAT is significantly lower, while the content of MDA is significantly higher in co-exposure solutions. The biochemical assays of head showed that, compare with single-exposure, co-exposure had more obvious effect on the activities of SOD, CAT and the content of MDA. Under the toxicity ratio of 1:1, Nano-ZnO increased the toxicity of PFOS on oxidative stress in liver, gill and head of zebrafish at the experimental concentrations.