New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities

摘要

Panax ginseng C. A. Meyer (Araliaceae), is a well-known herb and used in the old established system of Oriental remedy, especially in Japan, China and Korea. Four new compounds characterized as (cis)- 7@b,11@a,19,21-tetra-O-decanoyl-18, 22@b-dihydroxy-dammar-1-en-3-one (1), 3@b,4@a,12@b-trihydroxystigmast-5-en-21-yl octadecan-9',12'-dienoate (2), dammar-12, 24-dien-3@a, 6@b, 15@a-triol-3@a-D-arabinopyranosyl-6@b-L-arabinopyranoside (3) and dammar-24-en-3@a, 6@b, 16@a, 20@b-tetraol-3@a-D-arabinopyranosyl-6@b-D-arabinopyranoside (4) were isolated and established from the ethyl acetate and butanol extracts of the roots of P. ginseng. Their structures were established on the basis of spectral data and chemical reactions. Natural compounds indicative a great reservoir of materials and compounds with evolved biological activity, including antioxidant. Compounds 1-4 were investigated in vitro for antioxidant potential using ferric reducing antioxidant power (FRAP), the Nitric oxide (NO) scavenging activity, reducing power, phosphomolybdenum and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging actions, and the decision showed the compounds 3and 4 have probablyessential antioxidant properties than the compounds 1and 2 presented weak activity.