Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides

摘要

Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides[o-R1R1NCOC6H4CONR1R1], unsymmetrical o-phthalic acid diamides[o-R1R1NCOC6H4CONR1R2], and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides[o-R1R1NCOC6H4CONHAr], respectively.