Spindle cell Carcinoma is a rare biphasic neoplasm consisting of epithelial and mesenchymal components and accounts for less than 1% of all tumours of oral region. It is a rare aggressive variant of squamous cell carcinoma which frequently recurs and metastasizes with poor prognosis compared to classical squamous cell carcinoma. The biologic behaviour is comparable to poorly differentiated Squamous Cell Carcinoma. The 5 year disease free survival rate is approximately 30% for all Oral Tumors. The variants of squamous cell carcinoma frequently arise in mucosa of upper aerodigestive tract. The most common site in head and neck region is in larynx and hypopharynx; the oral cavity being rarely affected. This biphasic malignant neoplasm often assumes a sarcomatous appearance and may present diagnostic difficulty. Hence careful histopathologic analysis is warranted. We report a rare case of spindle cell carcinoma in unusual location with immunohistochemical findings and review of the literature.
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