Assessment of Neurometals in Neonates of Preeclamptic Mothers

摘要

Preeclampsia is a multisystem disease causing both maternal and fetal morbidity principally neurological tragedies. It may be associated with changes in concentrations of blood elements. We aim to assess neurometals; Selenium (Se), copper (Cu), zinc (Zn) and iron (Fe) concentrations in serum of 25 neonates of preeclamptic mothers and their mothers representing group (I) with comparison to 20 apparent healthy neonates and their healthy mothers representing group (II). Both groups were subdivided into two subgroups: a (Full Term) and b (Preterm). Results revealed that: Group (I) neonates had significantly (P < 0.01) lower Cu concentration than control (100.1 vs. 126.1 mg/dl) while, insignificant differences were observed between groups in serum Se, Zn and Fe concentrations. Higher levels of Zn, Cu and Fe were observed in full term neonates of preeclamptic mothers compared to preterm neonates of the same preeclamptic mothers. There was negative correlation between mean serum level of Se in preeclamptic mothers and weight of their neonates and also level of Cu of them was positively correlated with weight of their neonates. Positive correlation was found between mean serum level of Cu in preeclamptic mothers and that of their neonates. In conclusion, the studied neurometals may have influence on the health of pregnant women and fetus and their disturbance may contribute to pathogenesis of neurological complications in both mothers and fetuses. Screening status of these elements during pregnancy might be of value for correction of deficiencies with rationalized use to avoid dangerous excess with its neurological sequence.