Effect of annona muricata Seed Extract on Blood Glucose, Total and Differential White Cell Count after Repeated Exposure to Clozapine

摘要

The use clozapine as antipsychotic agent poses high risk of developing agranulocytosis and hyperglycemia. We investigated the ameliorative effects of annona muricata seed on blood glucose, total and differential white cell count after repeated exposure of rats to 20mg/kg of clozapine. Twenty male albino wistar rats were divided into group A (control) and B (experimental). Group B was administered 20mg/kg of clozapine daily. Clozapine was administered repetitively in group B rats at different periods of one week (group B1), 3 hours after one week (group B2), and three hours following the last three hours (group B3). After the last of administration of clozapine (group B3), the rats were randomly subdivided into group C and D and received 600 and 800 mg/kg of extract respectively for 3 days. Results showed increase (P < 0.05) in mean blood glucose and decrease (P < 0.05) in total white and differential white cell counts of B1, B2 and B3. Three days administration of annona muricata seed extract caused a significant reduction (P < 0.05) in mean blood glucose and further caused a decline in total and differential white cell count. Data conclude that annona muricata seed extract exerted hypoglycemic effect on clozapine treated rats without improving decreased total and white cell count.