Persistent blood eosinophilia and eosinophil activation marker in a severe case of eosinophilic gastroenteritis associated with multiple food allergies

摘要

We refer to an interesting paper published in your journal about eosinophil activation markers in clonal and non-clonal eosinophilia and we aim to add some correlations between clinical and laboratory parameters in a rare eosinophilic gas- trointestinal disorder [1]. Blood eosinophilia is a frequent condition in medical practice, due to a broad spectrum of diseases, usually reactive to allergies, parasitic infections, malignancies or autoimmune diseases and more rarely primary or idiopathic. Despite lacking sensitivity and sensi- bility, blood eosinophilia can be considered an important laboratory parameter, mainly in cases with persistent high values and when increased eosinophil activation serologic biomarkers and secondary organ dysfunction can be proved. Eo- sinophilic disorders of the gastrointestinal tract, mainly eosinophilic gastroenteritis (EGE) are rare and heterogeneous disorders, with about 300 cases published in the literature, characterized by eosinophilic infiltration and inflammation at different levels, are frequently accompanied by blood eosinophilia [2]. Up to 70 % of EGE pa- tients have a personal history of allergic disor- ders such as asthma, rhinitis, food allergies and drug allergies or eczema, suggesting the role of hypersensitivity reactions in disease pathogen- esis [3].