Assessment of the anti-biofilm activity and biocompatibility of novel PE and PVC polymers

摘要

Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans are opportunisticnosocomial pathogens responsible for a wide range of acute or chronic infections. The use ofindwelling medical devices increases the risk of emergence and progression of infections and worsenthe prognostic for patient, in part due to biofilm developed by these species on inert surfaces. Thus,infections with bacterial or fungal biofilms represent a major public health concern because biofilmgrowing cells are highly resistant to antibiotics, disinfectants and host immune defenses. In the lastyears, researcher focused on the development of new materials for biomedical use, with better physicochemical properties, capable to reduce microbial colonisation in order to decrease the risk of biofilmformed on their surface. Objective of this study was to determine the antimicrobial activity of some newPVC and polyethylene based biomaterials. The study was realized on some strains from patients withdifferent infections hospitalized in Cardiovascular Diseases "CC Iliescu" Fundeni - Intensive CareUnit, Department of Public Health – Bucharest. The strains were selected based on their multiresistance to antibiotics and their ability to develop biofilms in experimental conditions. The resultsproved that proposed materials were biocompatible and had the capacity to inhibit microbialadherence to inert substrate, being a good option in case of their use for medical surfaces and designof novel prosthetic devices.