Polymer-Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultra-Thin Universal Binary Anti-Biofilm Coating with Long-Term Activity

摘要

We created a highly durable thin hydrophilic coating which prevents protein deposition and biofilm formation over the long-term (>4 weeks). We altered and optimized the self-assembly process in PDA nanoaggregate formation and PDA particle formation. The interaction of PDA and ultra-high molecular weight polymers, and the polymer chain reorganization within the coating is crucial in generating a durable surface coating with excellent antibiofilm activity. An attractive feature of the coating is that it does not contain any antimicrobial agents which have the potential to significantly increase the development and spread of antibiotic resistance.