Elevated 1 Hour Glucose During Oral Glucose Tolerance Test- A New Parameter of Impaired Metabolism

摘要

Background and aims: Recently, large scale studies emphasized the idea of an excess of metabolic and cardiovascular risk in patients currently considered to have normal glucose tolerance but showing an elevated 1 hour glucose (≥155mg/dl) during oral glucose tolerance test (OGTT).Material and Methods: 75 subjects with normal glucose tolerance or impaired glucose tolerance were completely investigated. We evaluated the clinical and biological markers associated to insulin resistance and we calculated the cardiovascular risk of the subjects using the SCORE charts.Results and Discussions: Our data found statistically significant correlations between subjects with normal glucose tolerance and elevated 1 hour glucose and the following markers of insulin resistance: triglycerides to HDL-cholesterol ratio (TG/HDL-chol), Homeostatic Model Assessment (HOMA-IR), The Quantitative Insulin Sensitivity Check Index (QUICKI), fasting insulin, fasting glucose to fasting insulin ratio. Also, the subjects with elevated 1 hour glucose had a greater cardiovascular risk compared to subjects with 1 hour glucose Conclusions: This study identifies a category of subjects currently considered as normal glucose-tolerant individuals but with a special metabolic profile, an increased cardiovascular risk and an increased risk of developing diabetes.