Short report: Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sj?gren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

摘要

Primary Sj?gren’s syndrome (pSS) is asystemic autoimmune disorder characterisedby lymphocytic infiltration and dysfunctionof exocrine glands. The lymphocytic infiltratesin exocrine glands mainly consist of Thcells and B cells. A hallmark feature of pSSis B cell hyperactivity, including formationof autoantibodies, elevated serum IgG levels,increased numbers of B cells and IgG+/IgM+plasma cells in salivary glands, and formationof germinal centre-like structures in the salivaryglands associated with an increased riskof lymphoma development.1 2 Th cells and inparticular T follicular helper (Tfh) cells playan important role in activation of B cells andformation of germinal centre-like structures.