SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT PROPERTIES OF NEW 3-ALKYL (ARYL)-4-(3-HYDROXY-4-METHOXY-BENZYLIDENAMINO)-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-5-ONES

摘要

A series of novel 3-alkyl(aryl)-4-(3-hydroxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-j) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-j) with 3- hydroxy-4-methoxy-benzaldehyde (3). The new ten compounds were characterized using by IR, 1H-NMR, 13C-NMR and UV spectral data. In addition, the synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Compounds 3f and 3h showed best activity for the ferrous iron chelating activity and DPPH. radical scavenging activity