In search of novel low toxicity and potent pesticide lead compounds, eight title compounds were synthesized via the condensation reactions of 1-[(heteroaryl)methyl]-5-methyl-1H-1,2,3-triazole-4-carbonyl chlorides with 5-alkyl-2-amino-1,3,4-thiadiazoles, and structurally characterized by IR, 1H NMR spectra, and elemental analysis or further by MS technique. Preliminary bioassays showed that a fraction of the target compounds possessed moderate herbicidal activities against dicotyledonous plants (Brassica campestris L) at the concemtration of 100 mg/L and insecticidal activity to some extent at the concemtration of 250 mg/L.%为了寻找新型高效低毒的农药先导化合物,采用1-[(杂芳基)甲基]-5-甲基-1H-1,2,3-三唑基-4-甲酰氯与2-氨基-5-烷基-1,3,4-噻二唑的缩合反应,合成了8种未见文献报道的目标化合物,其结构经IR,1H NMR和元素分析确证,部分化合物还经MS的进一步证实.初步的生物活性测试结果表明,部分目标化合物在100 mg/L浓度下对双子叶植物(油菜)显示出中等的除草活性和一定程度的杀虫活性(250 mg/L).
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