The present study was aimed at evaluation of the anti-inflammatory, analgesic and antipyretic activities of petroleum ether and ethanolic extract of aerial parts of Mollugo pentaphylla Linn. In experimental standard models. The results showed that the ethanolic extract significantly reduce the edema induced by carrageenan within 1 to 3 hrs. post dosing and Cotton-pellet induced granuloma models than the petroleum ether extract at all the dose levels used. In analgesic activity by tail immersion and acetic acid induced writhing models, ethanolic extract significantly reduce the painful stimulus than petroleum ether extract. This confirms central and peripheral effects of the drugs. It also possess antipyretic activity, ethanolic extract significantly reduces fever at higher doses within 3 hrs. than petroleum ether extract on Brewer織s yeast induced pyrexia model in rats.
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