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首页> 外文期刊>Revista Brasileira de Zootecnia >Value of genomics in breeding objectives for beef cattle
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Value of genomics in breeding objectives for beef cattle

机译:基因组学在肉牛育种目标中的价值

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摘要

The objective of this research was to discern the contribution of genomic information to multiple-trait breeding objectives and thus understand the economic value of that information. True genetic values were simulated for each of n, possibly correlated, traits. These true genetic values, combined with uncorrelated random noise, resulted in both genomic and phenotypic estimated breeding values, EBVg and EBVp, respectively. The separate EBV were then merged (blended) as a function of their respective accuracies to produce a unified EBV for each of the n traits. Finally, for each simulated animal (N = 10000), the sum of products of economic weights and EBV was calculated to predict the economic value (net merit) of the individual. Accuracies of the EBV for the individual traits and net merit were calculated as correlations between predicted and true values. Predicted responses to selection for individual traits included in the breeding objectives were enhanced from 9% to 76% with the greatest benefit accorded to those economically relevant traits that are recorded after selection decisions are made at one year of age, measured less frequently in national cattle evaluation, or often predicted using information from indicator traits. Combining the EBV to predict net merit for terminal and maternal breeding objectives resulted in predicted increases in selection response due to incorporation of genomic information of 27% and 57%, respectively. The results are interpreted to suggest that the economic benefit to be derived from selection based on a multiple-trait economic breeding objective, which is predicted using genomically enhanced EBV, can substantially exceed the present day cost of genotyping the candidates for selection.
机译:这项研究的目的是辨别基因组信息对多特征育种目标的贡献,从而了解该信息的经济价值。为n个可能相关的性状中的每个性状模拟了真实的遗传值。这些真实的遗传值,加上不相关的随机噪声,分别导致了基因组和表型估计的育种值EBVg和EBVp。然后根据其各自的准确性合并(混合)单独的EBV,以针对n个性状中的每一个产生统一的EBV。最后,对于每只模拟动物(N = 10000),计算经济权重和EBV的乘积之和,以预测个体的经济价值(净值)。根据预测值和真实值之间的相关性,计算出每个特征的EBV准确性和净值。育种目标中对单个性状选择的预测反应从9%提高到76%,最大的收益与一年后做出选择决定后记录的那些与经济相关的性状相符,在本国牛中测量频率较低评估,或经常使用指标性状的信息进行预测。结合EBV来预测最终和母本育种目标的净值,由于分别引入了27%和57%的基因组信息,因此预测了选择反应的增加。解释结果表明,基于多性状经济育种目标从选择中获得的经济收益(使用基因增强的EBV预测)可以大大超过当今对候选基因进行基因分型的成本。

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