Influência da suplementa??o aguda e cr?nica de creatina sobre as concentra??es sanguíneas de glicose e lactato de ratos Wistar

摘要

Recent studies suggest that the creatine supplementation can interfere with glucose uptake and lactate production during the physical activity. The aim of this study was to investigate the effects of the short-term (5 g.kg1 for 1 week) and long-term (1 g.kg1 for 8 weeks) creatine supplementation on the plasmatic concentrations of glucose and lactate of sedentary and exercised (swimming to 80% of the tolerated maximum load) rats. Seventy two male Wistar rats (240 ± 10 g) were used and divided equally in 4 experimental groups (n = 18): CON - sedentary rats without supplementation; NAT - exercised rats without supplementation; CRE - sedentary rats with supplementation; CRE + NAT - exercised rats with supplementation. The blood samples were obtained weekly before and after the maximum load test. Before the maximum load test, except for the group CRE-NAT (3-5 weeks), that presented lower level of plasma glucose concentration in relationship the other groups, all the other results were similar among the experimental groups. After the maximum load test, all of the experimental groups presented reduction of the plasma glucose concentration and increase of the plasma lactate concentration. However, in relation to the glucose, this reduction was significantly (p < 0.05) pronounced in the groups CRE (1-4 weeks) and CRE + NAT (1-8 weeks), and in relation to the lactate, the increase was significantly (p < 0.05) smaller in the groups CRE (1-2 weeks) and CRE + NAT (1-8 weeks). The findings of this study suggest that the adopted regime of supplementation influenced the metabolic glycemic profile, minimized the lactate accumulation and increased the maximum load supported in the animals supplemented.