Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro

摘要

Two new flavonoids ( 1 and 2 ), named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids ( 3 a?? 9 ) were isolated from the aerial parts of Capsella bursa-pastoris (L.) Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds ( 1 a?? 9 ) were identified by their spectroscopic data and references. Moreover, compounds ( 1 a?? 9 ) were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2 , 3 , 6 , and 9 (10 ?μM) exhibited moderate hepatoprotective activities.