The relationship between pulmonary HRCT findings and peripheral blood immunological parameters in adults with H1N1 influenza

摘要

Purpose To investigate the correlations of pulmonary high-resolution computed tomography (HRCT) findings and their distribution with the peripheral blood immunological parameters of swine-origin influenza A (H1N1) infection. Materials and methods 173 patients with H1N1 influenza infection underwent HRCT. CD4 + and CD8 + lymphocyte counts and C-reactive protein (CRP) levels in the peripheral blood were measured on the day of admission. According to the predominant HRCT findings, we created three groups: Group A?=?normal attenuation, Group B?=?ground-glass opacity (GGO), Group C?=?consolidation with or without GGO. We classified the extent of lung lesions into five groups as follows: Group 1?=?CT score of 0; Group 2?=?CT score of 0.01–0.25; Group 3?=?CT score of 0.26–0.50; Group 4?=?CT score of 0.51–0.75; Group 5?=?CT score of 0.75–1.00. Results The CD4 + and CD8 + lymphocyte counts decreased with the degree of the attenuation and the extent of the lesions on HRCT (P??0.001), whereas the CRP levels increased with the degree of the attenuation and the extent of the lesions (P??0.001). Conclusions The HRCT findings correlated with the CD4 + and CD8 + lymphocyte counts and the CRP level in the peripheral blood of patients in the initial stage of influenza infections.