Bacteriologic Profile and Antibiotics Susceptibility Pattern of Suspected Septicaemic Patients in Uyo, Nigeria

摘要

Septicaemia is a common potentially life-threatening condition with significantly high morbidity and mortality. Due to the serious threat it poses to lives of patients and the fact that results of blood cultures take a while to be ready, effective empirical therapy would require that clinicians should be armed with the knowledge of current bacteriologic profile of septicaemia and their susceptibility patterns. This study is aimed at determining the bacterial profile of septicaemia and their susceptibility pattern in University of Uyo Teaching, South-South region of Nigeria. A total of 689 blood samples were aseptically collected from patients of various ages with suspected septicaemia admitted at University of Uyo Teaching Hospital (UUTH) from January 2011 to December 2012. The samples were inoculated into blood culture bottles containing brain heart infusion broth and thyoglycolate broth and incubated at 37°C, aerobically and anaerobically respectively. Subcultures were made, isolates were identified and antibiotics susceptibility set up using standard methods. Data was analysed using SPSS Version 16. The study showed that 161 (23.4%) were culture positive. The commonest bacterial isolates were Staphylococcus aureus (55.3%), Escherichia coli (18.0%), Klebsiella pneumoniae (11.2%) and Coagulase Negative Staphylococci (CONS) (4.3%). Ampicillin and amoxicillin/clavulanic acid were the most resistant antibiotics while imipenem and vancomycin were the most sensitive. Regular bacteriologic profile and antibiotics susceptibility surveillance studies is advocated for effective management of septicaemia.