Histopathological evidences for effect beneficial of walnut extract on hepatic lesion by cadmium-induced in Rat

摘要

Cadmium (Cd) is an important industrial and environmental pollutant. Cd is one ofthe most toxic and carcinogenic heavy metals to organisms. This heavy metalmainly distributes to the liver and kidney in humans and animal and causing acutehepatic injury. The ethanol extract of walnut leaf extract., a native plant from Iran ,was evaluated for its activity against Cd–induced. The ethanol extract of walnut leaf(100 and 200 mg/kg/day for 6 weeks) was examined on serum bicochemical andhepatic histopathological characteristic of males rats, which are Cd-induced (3mg/kg/day for 6 weeks). The biochemical results indicated that aspartatetransminase (AST) and alanine transaminase (ALT) significantly increased in serumby cadmium-induced in all treatments. The liver histopathological results revealedthat the ethanol extract of walnut leaf treatment at 200 mg/kg/day significantlyreduced toxicity by cadmium-induced. The ethanol extract of walnut leaf preventsthe cadmium-induced lesions in hepatic function. Known antioxidant, antimicrobial,antihepatotoxic, nephroprotective potentials of the extract of walnut leaf may be themechanisms by which this plant protects animals against experimentally cadmiuminduced.