Overview of Plant-based Vaccines

摘要

Plants are reviewed with regard to their ability to express and produce vaccines. Advancements in the field of plant biotechnology have brought optimism that vaccines and therapeutics produced in plant systems may be able to address numerous animal and human disease issues. Plant-produced vaccines are a much-hyped development of the last two decades, whose time to embrace reality may have finally come. Vaccines have been developed against viral, bacterial, parasite and allergenic antigens, for humans and for animals; a wide variety of plants have been used for stable transgenic expression. A great many products have shown significant immunogenicity; several have shown efficacy in target animals or in animal models. This review article includes historical development, promise vs reality, production, safety, efficacy and future of plant vaccines.