The Comparative Double Blind Clinical Study in Antihelmintic Efficacy Between Thai Traditional Herbal Formulae and Mebendazole

摘要

This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized control trial clinical study in order to examine the efficacy of TTHF in the treatment of antihelmintic activity of mixed worms infection in human. The experimental group consisted of 10 and 5 patients for control group with inclusion and exclusion criteria which were screened by the selection of mixed worm infection symptoms samples. The investigation and extraction of worm Eggs Per Gram of patient feces method (EPG) were performed with Ether Formalin Sedimentation Test. The percentage of reduction of Eggs Per Gram (EPG) of patient feces were collected, counted and confirmed by parasitologist and the clinical efficacy was investigated by the physician and the pharmacist. The EPG (%) data were collected before and after the treatment with TTHF and with Mebendazole. The result showed that TTHF had higher efficacy in antihelmintic activity than Mebendazole and placebo which had the reduction (%) of egg per gram of feces as 93.69 with TTHF and reduction (%) of egg per gram of feces as 87.50 in Mebendazole. The suggestion of this study should increase the number of samples of worm infected patients which the samples can be identified with the specific helminthes genus and species in order to obtain the efficacy by the treatment using TTHF and Mebendazole comparatively.