Design and development of fast Melting Tablets of Terbutaline Sulphate

摘要

Difficulty in swallowing leads to non-compliance and subsequently leading to ineffective therapy. Terbutaline Sulphate is a beta-2 agonist and has action similar to that of Isoproterenol. The basic aim of this formulation was to decrease the onset time of the drug by decreasing the disintegration time of the tablet by formulating fast melting tablet. In the present study fast melting tablets of Terbutaline Sulphate was prepared by using of superdisintegrants. The tablets were prepared by direct compression technique. Six formulations of tablets were prepared containing drug. Prepared tablets were evaluated on different parameters. Evaluation results shows tablet to be within the official limits. Wetting time and disintegration were in limits that are prescribed for mouth dissolving tablets. Dissolution profile of the tablet shows that the excipients used in the tablet had no negative influence on the release pattern of the drug. It was thus possible to formulate mouth melting tablets of Terbutaline Sulphate using simple and cost effective technique.