Synthesis, Structure and Antimicrobial Activity of new 3- and 2- arylmethyl and arylacyl-3H[1,2,4]triazino[3,2-b]-quinazoline-2,6(1H)diones as expected as DNA fluorphores

摘要

Starting from 2,3-diaminoquinazoline 3, a series of two isomers of new expected fluorescent 3- and 2-arylmethyl and arylacyl-3H[1,2,4]triazino[3,2-b]quinazoline-2,6(1H)diones 6 and 7 have been synthesized via its condensation with each of aryl pyruvic acid 4 and ethyl aroylpyruvates 5 depending upon the pH of the reaction medium. The structure of products was elucidated on the basis of their spectral, elemental analyses and alternate synthesis. The products 6 and 7 obtained are tested for antimicrobial activity and reported.