Utility of lingual examination in identifying sentinel pigs for porcine cysticercosis serological studies in Taenia solium endemic areas

摘要

LingualexaminationiscurrentlythemethodofidentifyingpigsforexperimentalstudiesonTaeniasoliumcysticercosisinendemicareas.nbsp;TheutilityoflingualexaminationinidentifyingsentinelpigsintendedformonitoringseroconversiontoT.soliumlarvalantigenwasassessed.nbsp;nbsp;Sensitivityoflingualexaminationindetectingpositiveresultsofantigenenzyme-linkedimmunosorbentassay(Ag-ELISA)was31.3%in251pigsaged4-7monthsand24.1%in440pigsaged9-12months.nbsp;Inbothagegroupsthespecificitywas99%.nbsp;Thelikelihoodratioforapositivelingualexaminationresultwas31.3and24.1inpigsaged4-7and9-12months,respectively.nbsp;Thelikelihoodratioforanegativelingualexaminationresultwas0.7and0.8,respectively.nbsp;Lingualexaminationof2-3monthsoldpigsinthreedifferentstudieshadpredictivevaluesforanegativetestof94.9%(95%CI:93.2,96.7;n=609),84.1%(95%CI:77.2,91.0;n=107)and100%(95%CI:100,100;n=96).nbsp;LingualexaminationisasuitablemethodforidentifyingpigsformonitoringAg-ELISAseroconversion.nbsp;Themethodismoresuitableforidentifyinginfectedthancysticercosis-freepigsasitsuffersfromahighlikelihoodoffalsenegativeresults.nbsp;Lingualexaminationisnotsuitableformonitoringtheincidenceofporcinecysticercosisseroconversionnorcanitenableapprovalofpigmeatforhumanconsumption.nbsp;StudiesareneededtodeterminetheutilityoflingualexaminationinselectingpigsintendedformonitoringT.soliumantibodyseroconversion.nbsp;Rapidantigendetectiontestsareneededtocomplementwiththelingualexaminationtoreducethelikelihoodsofinfectedpigsfromenteringthefoodchaininendemicareas.nbsp;nbsp;nbsp;nbsp;nbsp;