The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: A double-blind, randomized control trial

摘要

Background A dietary supplement containing a blend of 170?mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100?mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, many manufacturers attempt to determine the lowest efficacious dose. Thus, the purpose of this study was to evaluate the efficacy of 8-weeks of supplementation with a daily intake of 120?mg of NOPE and 105?mg of EGCG in conjunction with a low caloric diet and regular, moderate exercise on dietary compliance in healthy, overweight adults. An additional purpose was to examine the effect of this supplement/diet/exercise paradigm on changes in body composition, sensation of appetite, mood and severity of binge eating. Methods Fifty healthy, overweight (BMI?>?25?m·kg2) men (15) and women (35) (SUP; n?=?25; 32.7?±?13.75 y; BMI?=?33.4?±?6.2; PLA; n?=?25, 34.3?±?12.7?years; BMI?=?33.2?±?6.8) were recruited for a double-blind, placebo controlled study. Each volunteer was randomly assigned to either the supplement (SUP; n?=?25) or placebo group (PLA; n?=?25). Based upon a self-reported 3-day dietary recall all volunteers were recommended a 500?kcal or 30% (maximum of 1000?kcal) reduction in caloric intake. Volunteers were also encouraged to exercise 30?minutes per day, three times per week. Results Subjects in SUP were significantly more compliant (x2?=?3.86, p?=?0.049) in maintaining a low caloric diet at week 4, but this was not able to be maintained through the 8-week study. In addition, a significant difference in mood, feelings of fatigue and confusion were noted between the groups at week 4, but again not maintained by week 8 where only feelings of tension were improved. No differences between groups (p?>?0.05) were observed for body mass, body composition, feelings of hunger, and binge eating after eight weeks. Conclusion Supplementing with a combination of 120?mg of NOPE and 105?mg of EGCG does appear to enhance compliance to a low caloric diet and improve mood for 4 –weeks, but loses its effectiveness by week 8.