CHADS2 in Diabetic Patient as a Predictor of Contrast Induced Nephropathy in Elective Coronary intervention

摘要

Contrast induced nephropathy (CIN) is considered to be one of the record mutual main undesirable side effects of cardiac catheterization, and is concomitant with short- and long-term morbidity and mortality. The mode of inducing disease of CIN yet is not known completely in spite of some probabilities that CIN through inducing medullary hypoxia which leads to renal tubular damage. Objective: The aim of the study is to assess the efficacy of CHADS2 score in prediction of CIN in diabetic patient after elective coronary intervention. Methodology: This study was prospective cohort study conducted on 60 diabetic patients divided into two groups according CHADS2 score. All patients underwent elective percutaneous coronary intervention. All patients had the following: complete blood count, glycosylated hemoglobin (HbA1C), Resting 12-lead electrocardiography, Doppler – echocardiography. Serum creatininewas assessed at baseline, 24 hours after contrast media exposure in the coronary intervention. Creatinine clearance was assessed at baseline and 24 hours after the intervention. Results: CIN developed in 8 patients ((13.3%) one patient (2.6%) in CHADS2 score (1-2) group and 7 patients (33.3%) in CHADS2 score (>3) group. There are a significant positive correlation between the incidence of CIN and CHADS2 score. Conclusion: CHADS2 score is highly sensitive in diagnosis of contrast induced nephropathy after coronary intervention rather than old complicated scoring system.