Therapeutic role of ginger and chamomile aqueous extract for peptic ulcer using experimental rats.

摘要

This work was designated to clear out the effect of aqueaus extracts of ginger (Zingiber Officinale) family zingiberaceae and chamomile (Matricaria chamomilla) a member of Asteraceae family on healing aspirin induced ulcer in male albino rats. Thirty six male albino rats (150±10gb.wt. each) were used and disparted into 6 groups (n= 6 rats), one of them used as control-ve group while other 5 groups orally given aspirin (200mg/kg b.wt.), one of these groups left as control +ve and the rest groups orally administrated with aqueous extracts of ginger and chamomile at two doses of 200 and 400 mg/kg b.wt., for each of them for seven days. The length of gastric ulcer, the volume of gastric juice, pH, total acidity and histopathological changes were examined. The results concluded that oral administration with all doses of aqueous extracts of ginger and chamomile reduced the length of gastric ulcer, total acidity, volume of gastric juice and histopathological changes. On the other hand, all aqueous extracts increased pH value of gastric juice. According to the results, ginger and chamomile could be used for healing acute gastric ulcer disease especially ginger and chamomile water aqueous extract at doses of 400 mg/kg b.wt., for each of them.