Residual normal B-cell profiles in monoclonal B-cell lymphocytosis versus chronic lymphocytic leukemia

摘要

by the accumulation of mature CD5+/CD20lo/CD23+ clonalB-cells in peripheral blood (PB), bone marrow (BM), andother lymphoid tissues [1]. Currently, it is well-establishedthat CLL is systematically preceded by a pre-leukemicstage, known as monoclonal B-cell lymphocytosis (MBL)[2]; MBL includes both low-count (MBLlo) and high-countMBL (MBLhi), depending on the number of PB clonal Bcells (<0.5 × 109/L and ≥0.5 × 109/L, respectively) .