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The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human milk

机译:牛乳和人乳的糖,胰岛素和血浆氨基酸对等碳水化合物奶粉的响应

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Background Dairy proteins, in particular the whey fraction, exert insulinogenic properties and facilitate glycemic regulation through a mechanism involving elevation of certain plasma amino acids, and stimulation of incretins. Human milk is rich in whey protein and has not been investigated in this respect. Method Nine healthy volunteers were served test meals consisting of human milk, bovine milk, reconstituted bovine whey- or casein protein in random order. All test meals contributed with 25g intrinsic or added lactose, and a white wheat bread (WWB) meal was used as reference, providing 25g starch. Post-prandial levels in plasma of glucose, insulin, incretins and amino acids were investigated at time intervals for up to 2 h. Results All test meals elicited lower postprandial blood glucose responses, expressed as iAUC 0–120 min compared with the WWB (P?
机译:背景技术乳蛋白,特别是乳清级分,通过涉及某些血浆氨基酸升高和刺激肠降血糖素的机制,发挥胰岛素生成特性并促进血糖调节。人乳富含乳清蛋白,尚未对此进行研究。方法随机向9名健康志愿者提供测试餐,包括人乳,牛乳,重组牛乳清或酪蛋白。所有测试膳食均添加了25g固有或添加的乳糖,并使用白小麦面包(WWB)膳食作为参考,提供25g淀粉。餐后2小时内检查血浆中葡萄糖,胰岛素,肠降血糖素和氨基酸的餐后水平。结果与WWB相比,所有试验餐均引起较低的餐后血糖反应,表示为iAUC 0–120 min(P <0.05)。在所有测试餐后,胰岛素反应均增加,尽管在乳清后仅显着升高。血浆氨基酸与胰岛素和肠降血糖素分泌有关(iAUC 0-60分钟)(P≤≤0.05)。试验餐(iAUC 0–90分钟)降低的血糖与GLP-1(iAUC 0–30分钟)呈负相关(P≤≤0.05)。结论该研究表明,与WWB相比,所有以牛奶/牛奶蛋白为基础的测试餐后的血糖反应均显着降低。这种作用似乎源自蛋白质部分,早期血浆氨基酸和肠降血糖素与胰岛素分泌有关。尽管人乳中的蛋白质含量较低,但它是一种有效的GLP-1促分泌剂,并显示出与重组牛乳清蛋白相似的胰岛素生成特性,这可能是由于人乳中乳清的比例较高。

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