SD大鼠失禁性皮炎动物模型的建立

摘要

Abstract：Objective To establish an animal model of incontinence-associated dermatitis in SD rats by trypsin impregnation, which laid the foundation for further study of incontinence-associated dermatitis. Methods  The cotton balls soaked in saline with the control group were applied to the dorsal skin of SD rats with cotton balls soaked with trypsin solution. Three days after macroscopic the severity of IAD, including dermatitis occurrence range and severity score, were observed and recorded. Results  The dermatitis area, the severity of dermatitis and the recovery time of dermatitis were significantly higher in the experimental group than those in the control group(P0.05). Conclusion  The method of 4 g/100 mL trypsin immersion modeling is an simple, effective and easy way to reproduce. It is a modeling method worthy of popularization.