芒硝外敷对全膝关节置换术后肿痛疗效的Meta分析

摘要

Abstract：Objective To evaluate the effect of external mirabilite application on swelling and pain after total knee arthroplasty(TKA). Methods 〓Randomized controlled trials(RCTs)of external application of mirabilite which was used to treat swelling and pain after TKA were searched in databases. Data were collected and extracted by two researchers according to the inclusion and exclusion criteria. A Meta-analysis was performed by using a software of RevMan5.3. Results Totally 6 studies(365 patients)were included. In terms of pain, the difference was statistical significance on the second day(MD=-0.83, 95%CI: ［-1.00, -0.66］,P0.01), the third day(MD=-0.96, 95%CI: ［-1.65, -0.28］, P0.0)、the first week(MD=-1.71,95%CI: ［-2.53, -0.89］,P0.01)and the second week(MD=-1.17,95%CI: ［-1.90, -0.45］, P0.01)after surgery. In terms of swelling, there was significant difference in the first week(MD=-1.12,95%CI:［-1.35, -0.90］, P0.05)if measured 10 cm above knee-joint, and there was significant difference in the first week(MD=-1.12, 95%CI:［-1.35, -0.90］, P0.01)and in the second week(MD=-1.64, 95%CI: ［-1.83, -1.45］,P0.01)after surgery if measured 10 cm under knee-joint. Conclusion 〓The external mirabilite application is effective to relieve the swelling and pain after TKA. The efficacy is getting better with prolonged time of external application, and it has the advantages of less adverse reactions, unlimited use time, convenience in operation, low price and so on. It is worthy of clinical promotion, as an adjuvant treatment, for accelerating the rehabilitation of patients.