Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal duodenum

摘要

Background and Aims:Ingestion of food stimulates the secretion of incretin peptides glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 to ensure the proper absorption and storage of nutrients. Menin is the 67?kDa protein product of the MEN1 gene recently reported to have a role in metabolism. In this study, we will determine the regulation of menin in the proximal duodenum by food intake and diet in correlation with GIP levels in the proximal duodenum of mice after an 18?h fast followed by 4 and 7?h refeeding and 3 months of high-fat diet.