SUN-305 CELLULAR ORIGIN AND MICRORNA CONTENT OF PLASMA EXTRACELLULAR VESICLES IN DIABETIC NEPHROPATHY

摘要

Streptozotocin (STZ)-induced diabetes in male mice Jacking endothelial nitric oxide synthase (Nos3-/-) is a widely used model for examining the development of diabetic kidney disease (DKD). Female mice are partially protected from developing STZ-induced dia- betes due to their abundance of 17f-estradiol and lack of testosterone, and are not normally used for studies of DKD. In this study, we sought to identify whether male and female Nos3-/- mice with equivalent diabetes develop comparable renal injury, facilitating the potential to use both sexes in studies of DKD.