MON-216 URINE METABOLOMICS ANALYSIS TO INTRODUCE NEW MARKERS ASSOCIATED WITH THE PREDICTION AND EARLY DETECTION OF CONTRAST INDUCED NEPHROPATHY

摘要

These biomarkers were checked against significant variables obtained from OPLS-DA model of non-CIN population before and after angiog- raphy, to be sure that their changes are not caused by contrast agent. Conclusions: Differences in urine metabolomics patterns pre coronary angiography in patients, who will and will not develop CIN later, exist. Urine Metabolites may be potential early predictors of CIN . Differences in urine metabolomics patterns also exist in early post coronary angi- ography frame and can be used as new markers for early detection of post coronary angiography induced CIN even as early as 6 hours after contrast administration.