MON-011 A CASE SERIES OF MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE (MGRS) IN THE CONTEXT OF MONOCLONAL IMMUNOGLOBULIN DETECTION

摘要

IF) pathological findings (trans-sectional descriptive study). Introduction: Henoch-Schénlein purpura nephritis (HSPN) is a common secondary glomerulonephritis, which can cause end-stage renal disease (ESRD) or death. Owing to a relatively lower incidence of adolescent and adult patients, the clinicopathological features and the patho- physiological process of HSPN are not fully elucidated. Bilirubin, a degradation product of heme, has been identified as an endogenous antioxidant and cellular protectant, with potent abilities of complement inhibitory and anti-inflammatory. However, correlation between serum bilirubin level and progression of HSPN is not still illuminated. Therefore, the present study was conducted to evaluate whether serum bilirubin levels could serve as an independent predictor of HSPN and clarify the potential influence of serum bilirubin on development of HSPN.