Is Nonprotein Nitrogenous Compounds Have Role in Preeclampsia

摘要

Introduction: Preeclampsia is a pregnancy-specific disorder, which is life-threatening, both to foetus as well as mother. It may lead to early onset of CVD risk and stroke. Chronic kidney disorders may also lead to preeclampsia. Non protein nitrogenous substances urea, uric acid, creatinine are considered to have role in preeclampsia and determination of these markers during pregnancy is important to diagnose kidney function especially at women with preeclampsia signs.Materials and Methods: Thirty women diagnosed to have preeclampsia and thirty women (age matched) with normal pregnancy were taken as controls. Blood pressure measurements were done by using a sphygmomanometer and biochemical parameters like serum urea, uric acid, and creatinine were measured by using commercial kits. Statistical analysis were done by unpaired t- test.Results: A significant increase of SBP, DBP, Uric acid and Urea levels (P<0.05) have been seen in woman with preeclampsia compared to normal pregnancy but, the levels of creatinine doesn’t show any significant differences between two groups.Conclusion: Creatinine, urea and uric acid are non-protein nitrogenous metabolites that are cleared from the body by the kidney through glomerular filtration and also used as indicators of kidney function and other conditions. Determination of these parameters in serum during pregnancy helps to diagnose kidney function especially at women with preeclampsia signs. In the present study it was showed that uric acid might be having a role in preeclampsia even though urea levels were elevated. It was found of little value and creatinine had no predictive value in preeclampsia. Further studies with large samples were needed in order to get a clear clinical picture of these parameters in the issue of preeclampsia.