Angiogenin gene polymorphism: A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population?*

摘要

Research Highlights (1) We investigated genetic associations between angiogenin gene polymorphisms and diabetic peripheral neuropathy in the Han population of northern China. (2) Using a case-control design, we compared the genotype and allele frequencies of the angiogenin coding region single nucleotide polymorphism rs11701 between a diabetic neuropathy group and controls. No significant associations were found. (3) Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the northern Han Chinese population. Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we sequenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus (129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy patients) and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.