Hepatitis B and C Virus Infections among Blood Donors in Blood Transfusion Center, Pokhara, Nepal: Seroprevalence and its Associated Risk Factors

摘要

Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections lead to chronic diseases andare the most common causes of liver cirrhosis and cancer in developing countries like Nepal.The study is carried out to determine the seroprevalence of HBV and HCV by using a Rapidkit method and Elisa Method to find out its risk factors. The cross-sectional study was doneamong blood donating people from 16th August 2016 to 19th November 2016. Blood donors inPokhara Valley were screened for anti-HCV antibodies, anti-HBV antibodies using thirdgeneration ELISA kits and automated ELISA Processor in serology laboratory at Central BloodTransfusion Service (CBTS) of Nepal Red Cross Society (NRCS) in Pokhara, Nepal. 1777(87.2%) units were male blood donors and 260 (12.6%) units were female donors out of 2037participants. Gender wise, the ratio between male and female was 1:0.1. HBV and HCVinfection rate in blood donors were detected at 0.7% (15/2037) and 0.5% (8/2037) respectively.HBV infection rate in volunteer blood donor people was 0.7% (14/1881) which was higherthan the replacement donors i.e. 0.6% (1/156). Similarly, in HCV infection rate in volunteerdonor were 0.4% (8/1881). HBV infected people are detected higher than the HCV infectedpeople among the blood donors. In addition, there was no significant relationship betweenpositive results of HBV and HCV tests with the gender, age, tattoo, donor type.