Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity

摘要

Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis -diamminediiodoplatinum ( cis- DIDP) was loaded, cis -DIDP@PCL, which effectively overcame cis- DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis -DIDP were reduced greatly. In vitro, cis- DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis- DIDP, even better than cisplatin. Furthermore, cis -DIDP@PCL could controllably release cis- DIDP in different sustained-release solution based on our experiment.