Diverse Polyphenols from Hypericum faberi

摘要

Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A–F ( 1 – 6 ), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B ( 1 / 2 ) and 12 – 13 were isoprenylated xanthones, hyperfaberols C–E ( 3 – 5 ) and 8 – 11 were seven isoprenylated acylphloroglucinol derivatives, while 6 – 7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively. Graphical Abstract Electronic supplementary material The online version of this article (10.1007/s13659-019-0206-1) contains supplementary material, which is available to authorized users.