Relation between Weight, Height, Glycemic Status and Parasympathetic Functions in Nondiabetic Offspring of Type 2 Diabetes Mellitus

摘要

Objective: Diabetes Mellitus is group of common metabolic disorders that share the phenotype of hyperglycemia. Type 2 diabetes mellitus is a familial disease with a lifetime risk of 40% if one parent has Type 2 diabetes. Overweight is the second risk factor for type 2 diabetes mellitus. Till now, very few studies have shown early outcome of genetic transmission on cardiac autonomic activity among healthy offsprings with parental type 2 diabetes mellitus. Thus, the aim of this study was to examine the impact of parental Type 2 diabetes on autonomic nervous system and to determine whether autonomic neuropathy is present and its association with glycemic status, weight and height. Method: The cross-sectional study of Height, Weight, Glycemic status and Cardiovascular Autonomic Functions was carried out in 30 healthy offsprings of Type 2 Diabetic Parents (Study group) and 30 healthy offsprings of Nondiabetic Parents (Control group) in the age range of 18 - 21 years. Results: There is insignificant decrease in parasympathetic functions and insignificant increase in Fasting and Postload Blood Glucose in Study Group. There significant increase in weight, and height of subjects of Study Group. Conclusion: Our observations indicate that subclinical autonomic dysfunction may develop without the presence of long-term hyperglycemia in family members of type 2 diabetic subjects; Insulin resistance is a function of fat mass & because increasing body weight in the industrialized world has been accompanied by earlier presentation or acceleration of Type 2 Diabetes Mellitus. Different factors (including hyperglycemia) could subsequently affect the expression of the genes and influence the progression of neuropathy.