Exploring a Novel Screening Method for Patients with Oral Squamous Cell Carcinoma: A plasma Metabolomics Analysis

摘要

Aim: This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC). Patients & Methods: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates. Results: We selected four biomarker candidates against OSCC. Their sensitivity was more than 90%, and the AUC was over 0.9 according to the receiver operating characteristic curve analysis. Conclusions: The findings of this study suggest four potential metabolites as biomarkers for OSCC screening.