Cortical Layer V Neurons in the Auditory and Visual Cortices of Normal, Reeler, and Yotari Mice

摘要

Both in the Reelin-deficient reeler and Dab1-deficient yotari mice, layer Vcorticospinal tract neurons in the sensory-motor cortex are radially spread instead ofbeing confined to a single cortical layer. In the present study, we examined distributionpattern of cortical layer V neurons in the visual and auditory cortices of reeler andyotari mice with the injection of HRP into the superior and inferior colliculi of the adultanimals, respectively. After the injection of HRP into the superior colliculus of thenormal mouse, retrogradely labeled cells were distributed in layer V of the visualcortex, while the similar injection of HRP in the reeler and yotari mice produced radialdispersion of retrograde labeling through all of the depths of the visual cortex of thesemutant mice. Next, we injected HRP into the inferior colliculus of the normal, reelerand yotari mice. Retrogradely labeled neurons were distributed in layer V of thenormal auditory cortex, whereas they were again radially scattered in the auditorycortex of the reeler and yotari mice. Taken together with the previous and presentfindings, layer V cortical efferent neurons are radially scattered in the sensory-motor,visual and auditory cortices of the reeler and yotari mice.