Non-Invasive Parameters, Including a Low Left Ventricular Ejection Fraction, for Predicting Sudden Cardiac Death in Korean Post Myocardial Infarction Patients

摘要

Background and Objectives According to the MADIT II criteria, a low left ventricular ejection fraction (LVEF) is one of the most important predicting factors for sudden cardiac death (SCD) in post myocardial infarction (PMI) patients, and it is a reasonable indication for ICD implantation. The aim of this study is to reveal the incidence and the prognostic value of the non-invasive parameters and whether the MADIT II criteria for ICD implantation can be applied to Korean PMI patients. Subjects and Methods During the period from January 2001 to June 2005, 640 PMI survivors were included in this study. The incidence of an abnormal SAECG, premature ventricular complex (PVC) counts ≥ 10/hr, non-sustained ventricular tachycardia (NSVT) on ambulatory ECG and a low (≤ 30%) LVEF were studied and used as risk stratification markers for later adverse arrhythmic events. Results The incidence of PVCs ≥ 10/hr and NSVT on the ambulatory ECG was 14.3% and 7.5%, respectively. 29 patients (4.9%) had a LVEF of less than 30%. Arrhythmic events occurred in 9 of the 29 patients (31%). SCD or adverse arrhythmic events occurred in 42 of the 640 patients. The percentage of patients who were using β-blocker was lower than that in the MADIT II study group (55% vs 70%, respectively). In the adverse arrhythmic event (+) group, the percentage of β-blocker use was significantly lower than that in the arrhythmic event (-) group (32.5% vs 58%, respectively). Conclusion The MADIT II criteria and PVCs ≥ 10/hr or NSVT on the ambulatory ECG can be suggested as the indications for implanting an ICD in Korean PMI patients. The use of β-blocker is important for preventing adverse arrhythmic events.