Effects of Antioxidant Supplementation on the Lipid Peroxidation and Antioxidative Enzyme Activities in Patients with Coronary Heart Disease

摘要

Background and Objectives The purpose of this study was to evaluate whether antioxidant supplementation with tocopherol, vitamin C, β-carotene, and selenium reduces lipid peroxide levels and increases antioxidative enzyme activities in patients with coronary heart disease. Subjects and Methods Eighty nine patients participated in a randomized, double-blind, placebo-controlled trial. The antioxidant group (45 patients) was given daily doses of tocopherol (400 IU), vitamin C (500 mg), β-carotene (15 mg), and selenium (50 microgram) and the placebo group (44) received placebo. Thirty eight of the antioxidant group (84.4%) and thirty nine (88.6%) of the placebo group completed the 3-month supplementation. Results Serum levels of α-tocopherol, vitamin C and β-carotene were significantly increased in the antioxidant group as compared to the placebo group (p Conclusion These results suggest that antioxidant supplementation with tocopherol, vitamin C, β-carotene and selenium in patients with coronary heart disease may provide a prophylactic effect against oxidative stress.