Secondary metabolites from Phomopsis sp. A123

摘要

Graphical Five novel nonenolides, phomolides D–H (1–5), and phomonol (6), phomotone (7) and phomopene (8), plus previously know compounds 4-formyl-7-methoxyl-6-methyl-phthalide (9), dihydrogladiolic acid methyl lactal (10), cytochalasin H (11) and cytochalasin J (12) were isolated from the endophytic fungal strain Phomopsis sp. A123. This strain was isolated from leaves of the mangrove species, Kandelia candel , collected in the Fugong Mangrove Conservation Area, Fujian, China. The chemical structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR, and on the basis of HR‐Q‐TOF mass spectrometry. Antibacterial assays with the novel compounds 1–8 were carried out; they had no effect on the growth of the tested bacteria or yeasts.